LABORATORY AND NEUROSONOGRAPHIC PARAMETERS OF NEWBORNS WITH PERINATAL HYPOXY-ISCHEMIC ENCEPHALOPATHY

Abstract

The most common cause of perinatal damage is hypoxic-ischemic encephalopathy (HIE), which occurs in half of all cases of central nervous system pathology. The purpose of our work was to determine the laboratory and neurosonographic parameters of newborns born with perinatal hypoxic-ischemic encephalopathy. Materials and methods: 120 babies diagnosed with moderate and severe hypoxic-ischemic CNS lesions were under our observation. Group I included 40 newborns with moderate-degree hypoxic-ischemic encephalopathy, group II combined 40 newborns with similar pathologies but with severe-degree encephalopathy. Results: our analysis of the relative risk (RR) indicators in newborns of the main and control groups allows us to conclude that the modifying risk factors for the development of moderate-degree perinatal encephalopathy are the threat of miscarriage, toxicosis, mother's age over 35, moderate-degree anemia, acute upper respiratory tract infections, and gynecological pathology. We also established that the modifying risk factors for the development of severe perinatal encephalopathy are stillbirth, bad habits in the father, close marriages, obesity, chronic infection foci, acute bacterial infectious diseases, and urogenital infection. Conclusions: we established significant correlations between blood oxygen saturation, blood acid-base, and gas composition indicators in newborns with signs of hypoxic-ischemic perinatal encephalopathy, which should be used for diagnostic purposes and for predicting the severity of perinatal encephalopathy.