CHANGES IN INFLAMMATORY MARKERS AND VITAMIN D LEVELS IN CHILDREN WITH CYSTIC FIBROSIS IN THE ARAL SEA REGION

Abstract

Relevance. Cystic fibrosis (CF) is a severe hereditary disease in which, as a result of impaired mucociliary clearance and the formation of thick and viscous secretions, the bronchopulmonary system is mainly affected. The addition of infection and the accumulation of purulent sputum in the respiratory tract leads to obstruction of the small bronchi and the development of respiratory failure. Over the past decade, the quality and life expectancy of CF patients have improved significantly due to the improvement of therapeutic approaches and the development of new methods of influencing the pathogenetic mechanisms of disease formation. The purpose of the study. The aim of the study was to study changes in inflammatory markers and vitamin D levels in children with cystic fibrosis in the Aral Sea region. Materials and methods. 190 children with a mixed form of cystic fibrosis aged from 6 months to 14 years, who were under observation at the Republican Specialized Scientific and Practical Medical Center of Pediatrics and at the Medical Center of Khorezm region, were examined. Results and discussion. In children with cystic fibrosis in the acute phase of the disease, the PCT index increased to 5.4±0.5 ng/l (P<0.001) by 33.7 times compared with the normative data, and the concentration of CRP increased to 34.9±2.8 mg/l (P<0.001) by more than 9.0 times compared with the normative data. Vitamin D deficiency (25(OH)D 10-20 ng/ml) in the Aral Sea region was 1.6 times higher in 15 (41.7%) children with CF (P<0.001) compared with children with CF in the Republic (24 (32.4%)). Conclusion. The conducted studies have shown that the analysis of the concentration of inflammatory biological markers in combination with other diagnostic indicators can be useful for monitoring pulmonary inflammation and preventing unjustified prescribing of antibiotics. The increased vitamin D deficiency in the group of children with CF is explained by impaired pancreatic function in patients, which leads to a lack of fat and fat-soluble vitamins, and taking into account the number of sunny days per year and their duration, it can be explained by the lack of preventive measures for vitamin D deficiency in Uzbekistan.