MORPHOLOGICAL FEATURES OF THE SKIN OF CHILDREN WITH ATOPIC DERMATITIS ON THE BACKGROUND OF CHRONIC OBSTRUCTIVE BRONCHITIS
Abstract
Relevance. Atopic dermatitis (AD) is one of the most common childhood atopic diseases characterized by early onset, polymorphism of clinical manifestations and various pathomorphological features, as well as a tendency to develop into another atopic pathology during the patient's lifetime. The purpose of the study. Investigation of the morphological nature of the skin of patients with atopic dermatitis in conditions of chronic obstructive bronchitis. Materials and methods. The study presents methods of histological examination of clinical, anamnestic, laboratory and skin biopsies (24) of children with chronic obstructive bronchitis (42), suffering from chronic obstructive bronchitis (148) and accompanied by chronic obstructive bronchitis. Skin biopsies of children with asthma and chronic obstructive bronchitis were studied to study changes in the skin structure. The results of the study. Analysis of skin biopsy samples from children with atopic dermatitis revealed invaginations of the stratum corneum, focal parakeratosis, uneven acanthosis, and intercellular edema in the spinous layer, as well as hyperkeratosis. In certain areas, vacuolar dystrophy of basal layer cells was observed. The dermis exhibited edema, an increase in collagen fiber volume, basophilic changes, and dilation of blood vessels in the upper and middle layers. The endothelium was edematous, with pronounced lymphohistiocytic infiltrates containing neutrophils and eosinophils detected around the blood vessels. Conclusion. The study results are essential for understanding atopic dermatitis and its morphological changes and contribute to developing modern approaches to disease diagnosis and therapy.
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