ENDOKRIN BEPUSHTLIKDA VISFATIN VA FOLLISTATIN DARAJALARINING PATOGENETIK XUSUSIYATLARINI VA KLINIK AHAMIYATINI O‘RGANISH
Abstrakt
Maqsad: Ushbu tadqiqot ortiqcha vazn va I-II darajali semizligi bo‘lgan ayollarda endokrin bepushtlikning rivojlanishida neogormonlarning ahamiyatini baholash hamda modda almashinuvi buzilishlari, gormonal muvozanatsizlik va reproduktiv funksiyaning izdan chiqishi o‘rtasidagi o‘zaro bog‘liqlikni aniqlashga qaratilgan. Tadqiqotning dolzarbligi reproduktiv yoshdagi ayollar orasida semizlikning tobora keng tarqalishi va neogormonlarning endokrin bepushtlik patogenezidagi roli haqidagi tushunchalarning cheklanganligi bilan asoslanadi. Materiallar va usullar: Tadqiqotga reproduktiv faoliyati buzilgan va turli darajadagi ortiqcha tana vazniga ega bo‘lgan 114 nafar ayol jalb etildi. Klinik baholash, gormonal profillarni o‘rganish, uglevod va lipid almashinuvini tahlil qilish hamda jigar faoliyatini tekshirish o‘tkazildi. Leptin, adiponektin va boshqa metabolik faol peptidlar kabi neogormonlar darajasi standart laboratoriya usullari orqali aniqlandi. Natijalar: Metabolik ko‘rsatkichlarda sezilarli farqlar aniqlandi, bu esa yog‘ to‘qimalari disfunksiyasi va neyroendokrin boshqaruvdagi buzilishlar darajasini ko‘rsatib berdi. Leptin miqdorining yuqoriligi va adiponektin konsentratsiyasining pastligi insulinga chidamlilik belgilari, jigar fermentlari faolligining ortishi va salbiy lipid profili bilan bog‘liq ekanligi aniqlandi. Neogormon sekretsiyasida sezilarli o‘zgarishlarga ega ayollarda anovulyator sikllar va tuxumdon zaxirasining pasayishi ko‘proq kuzatildi. Bu natijalar semizlikka chalingan ayollarda endokrin bepushtlikning rivojlanishida moddalar almashinuvining buzilishi muhim ahamiyatga ega ekanligini tasdiqlaydi. Yangilik: Tadqiqot semiz ayollarda neogormonlar darajasi, metabolik holat va reproduktiv tizim buzilishlari o‘rtasidagi keng qamrovli aloqani aniqladi. Olingan natijalar metabolik kasalliklar fonida bepushtlik rivojlanishi mexanizmlari haqidagi zamonaviy bilimlarni kengaytiradi hamda neogormonlarning biomarkerlar sifatidagi potensial tashxis qiymatini ko‘rsatadi. Xulosa: Tadqiqot natijalari semizlik va reproduktiv kasalliklarga chalingan ayollarda metabolik va gormonal holatni, jumladan neogormonlarni baholashni muntazam nazorat qilishning muhimligini ko‘rsatmoqda. Endokrin buzilishlarni tashxislash va davolashga kompleks yondashuv bepushtlikni davolash samaradorligini oshirishi va reproduktiv natijalarni yaxshilashi mumkin.
Mualliflar haqida
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