Differentsiatsiyalanmagan biriktiruvchi to'qima displaziyasi bo'lgan o'smirlarda bronxial astma: Th17 sitokinlari, D vitamini va mikroelementlar nomutanosibligining roli
Annotatsiya
Kirish. Bronxial astma - bu nafas yo'llarining surunkali yallig'lanish kasalligi bo'lib, bronxial giperreaktivlik va nafas yo'llarining qayta tuzilishi bilan tavsiflanadi. So'nggi yillarda o'smirlarda bronxial astmaning rivojlanishi va rivojlanishida differentsiatsiyalanmagan biriktiruvchi to'qima displaziyasining (UCTD) roliga tobora ko'proq e'tibor qaratilmoqda. Biriktiruvchi to'qimaning strukturaviy anomaliyalari bronxial devor arxitekturasining o'zgarishiga, yallig'lanish jarayonlarining kuchayishiga va kasallikning klinik kechishining yomonlashishiga yordam berishi mumkin. Tadqiqot maqsadi. Differentsiatsiyalanmagan biriktiruvchi to'qima displaziyasi bilan bog'liq bronxial astma bilan og'rigan o'smirlarda Th17 sitokinlarining (IL-17), o'zgaruvchan o'sish omili-β (TGF-β), D vitamini holati va mikroelementlar balansining (rux va magniy) rolini baholash. Materiallar va usullar. Tadqiqotga 12-17 yoshdagi 182 o'smir kiritilgan. Asosiy guruh bronxial astma bilan birgalikda UCDD bilan og'rigan bemorlardan (n=92), taqqoslash guruhi UCDDsiz bronxial astma bilan og'rigan bemorlardan (n=60) va nazorat guruhi deyarli sog'lom o'smirlardan (n=30) iborat edi. Klinik, laboratoriya, immunologik va biokimyoviy tadqiqot usullari qo'llanildi. IL-17, TGF-β, IgE, D vitamini, rux va magniy darajalari baholandi. Natijalar va muhokama. UCDD bilan bog'liq bronxial astma bilan og'rigan o'smirlarda IL-17, TGF-β va IgE darajalari sezilarli darajada yuqori, shuningdek, D vitamini, rux va magniy darajalari nazorat guruhiga nisbatan ancha past edi (p<0.05). Ko'p o'zgaruvchan regressiya tahlili shuni ko'rsatdiki, IL-17 darajasining oshishi va D vitamini yetishmovchiligi og'ir bronxial astmaning mustaqil bashorat qiluvchi omillari hisoblanadi. Olingan ma'lumotlar nafas yo'llarining qayta tuzilishi va kasallikning rivojlanishida immunitet disregulyatsiyasi va biriktiruvchi to'qima anomaliyalarining ishtirokini ko'rsatadi. Xulosa. Olingan natijalar shuni ko'rsatadiki, UCTD bilan bog'liq astma bilan og'rigan o'smirlarda sezilarli immun va metabolik buzilishlar kuzatiladi, bu esa kasallikning og'irligi va rivojlanishiga hissa qo'shishi mumkin. Sitokin profilini, D vitamini holatini va mikroelementlar balansini baholash ushbu bemorlar guruhida astma tashxisini qo'yish va davolashni yaxshilash uchun muhim bo'lishi mumkin.
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