Tug‘ma yurak nuqsonlari bo‘lgan bolalarda ichak mikrobiomining metabolik kooperatsiyasi hamda proteolitik faolligi
Annotatsiya
Kirish. Tug‘ma yurak nuqsonlari bo‘lgan bolalarda ichak mikrobiomining buzilishi uning metabolik faolligi o‘zgarishi bilan kechadi. Ushbu o‘zgarishlarning eng muhim funksional biomarkerlari qisqa zanjirli yog‘ kislotalari (QZYK) hisoblanadi. Tadqiqotning maqsadi. Tug‘ma yurak nuqsonlari bo‘lgan erta yoshdagi bolalarda qisqa zanjirli yog‘ kislotalari hosil bo‘lishining yoshga oid xususiyatlari hamda ichak mikrobiomining funksional holatini o‘rganish. Materiallar va usullar. Tug‘ma yurak nuqsonlari bo‘lgan erta yoshdagi bolalar hamda nazorat guruhidagi sog‘lom bolalarning najas namunalarida qisqa zanjirli yog‘ kislotalari profili o‘rganildi. Atsetat, propionat, butirat, tarmoqlangan yog‘ kislotalari yig‘indisi, IsoCn/Cn nisbati va anaerob indeks M.D. Ardatskaya usuli bo‘yicha gaz-suyuqlik xromatografiyasi yordamida aniqlandi. Bolalar uch yosh guruhiga ajratildi: 0–6 oy, 6–12 oy va 1–3 yosh. Natijalar va muhokama. Tug‘ma yurak nuqsonlari bo‘lgan bolalarda barcha yosh guruhlarida ichak mikrobiomining metabolik faolligi buzilgani aniqlandi. Eng yaqqol o‘zgarish butirat ishlab chiqarilishining kamayishi bo‘lib, bu 6–12 oylik bolalarda nazorat guruhiga nisbatan 3,7 marta past bo‘ldi. Shuningdek, propionat miqdorining kamayishi, anaerob indeksning pasayishi va proteolitik metabolizm ustunligini aks ettiruvchi IsoCn/Cn nisbatining oshishi kuzatildi. Aniqlangan o‘zgarishlar butirat ishlab chiqaruvchi obligat anaerob bakteriyalar faolligining pasayishi, saxarolitik fermentatsiyaning buzilishi va ichak mikrobiotasining funksional metabolik yetishmovchiligi shakllanishini ko‘rsatadi. Xulosa. Tug‘ma yurak nuqsonlari bo‘lgan erta yoshdagi bolalarda qisqa zanjirli yog‘ kislotalari ishlab chiqarilishining yoshga bog‘liq buzilishlari aniqlandi. Ular butirat va propionat tanqisligi, proteolitik metabolizmning kuchayishi hamda obligat anaerob ichak mikrobiotasi funksional faolligining pasayishi bilan tavsiflanadi.
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