Modern Clinical and Epidemiological Features of The Course of Hemorrhagic Vasculitis in CHildren

Abstract

Introduction. According to the literature, hemorrhagic vasculitis (Henoch-Schonlein purpura) is one of the most common systemic vasculitis in children. In recent years, the disease has been increasing not only in preschool and primary school children, but also in adolescents, and often develops in connection with respiratory infections, allergic conditions, and changes in the immune system. The aim of the study is to study the modern clinical and epidemiological characteristics of the course of hemorrhagic vasculitis (Henoch–Schonlein purpura) in children. Materials and methods. A retrospective analysis of the scientific literature published in the last decade on hemorrhagic vasculitis (Henoch–Schonlein purpura) in children was performed. The obtained data were mathematically verified and compared by year. Results and discussion. The results of the study showed that the formation of immune complexes, inflammation of the vascular walls, and microcirculation disorders play an important role in the pathogenesis of the disease. In the clinical picture, hemorrhagic skin rashes, joint and abdominal syndromes, kidney damage, and mixed symptoms are the leading ones. Also, the course of the disease has individual characteristics, and its severity is determined by the main clinical symptoms and the development of complications. Conclusion. The scientific data obtained as a result of the study indicate that in-depth study of modern clinical and epidemiological characteristics is important for early detection of hemorrhagic vasculitis, assessment of risk factors, and prognosis of the course of the disease.