THE ROLE OF GESTATIONAL AGE IN THE CLINICAL PICTURE OF HYPOXIC-ISCHEMIC ENCEPHALOPATHY IN NEWBORNS
Abstract
Introduction. Hypoxic-ischemic encephalopathy (HIE) is a severe lesion of the central nervous system of newborns, resulting from acute or chronic intrauterine hypoxia and/or asphyxia during childbirth. The purpose of this study was to investigate the effect of gestational age on the clinical picture of hypoxic-ischemic encephalopathy (HIE) in newborns.Materials and Methods: The study included 43 newborns admitted to the maternity ward of the Regional Perinatal Center of Samarkand in 2023–2024, who were diagnosed with hypoxic-ischemic encephalopathy (HIE) and were treated in the neonatal intensive care unit. All patients were divided into three groups according to gestational age.Results. The study demonstrated that in newborns who experienced hypoxic-ischemic encephalopathy (HIE), the clinical manifestations of the disease depend on gestational age.Discussion. The study shows a pronounced effect of gestational age on the clinical picture and laboratory parameters of newborns with hypoxic-ischemic encephalopathy (HIE).Conclusion. The results of the study indicate that gestational age has a significant impact on the clinical picture and laboratory parameters of HIE in newborns. Premature infants predominantly exhibit signs of CNS depression, term infants have a more diverse clinical picture, and post-term infants have the most severe course of the disease.
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